Laura Segatori named AIMBE fellow

Bioengineer focuses on cellular mechanisms that lead to therapies


Rice University bioengineer Laura Segatori has been named a fellow of the American Institute for Medical and Biological Engineering (AIMBE).

She is one of 175 new fellows elected this year by peers and members of the AIMBE College of Fellows for her “outstanding contributions to the development of protein engineering and synthetic biology tools for biomanufacturing technologies and cell therapies,” according to the institute.

Election to the college is among the highest professional distinctions accorded to a medical and biological engineer, with members representing the top 2% of the medical and biological community.

Segatori, an associate professor of bioengineering, chemical and biomolecular engineering and biosciences, and her Cell and Protein Engineering Laboratorydevelop system-level strategies that integrate synthetic biology, protein engineering and bionanotechnology to reprogram the quality control mechanisms in mammalian cells. These allow for a broader understanding of molecular mechanisms that regulate protein processing, and aid in the development of cell-based therapies and the production of biologics.

She has pioneered the development of approaches for ensuring proper protein processing and directing the elimination of aberrant proteins via targeted intracellular proteolysis, both of significance in numerous disease states, especially neurodegeneration and inflammation.

“My group has created an array of cutting-edge approaches to regulate protein synthesis and degradation, thereby controlling dynamic protein behaviors in cells with exquisite specificity,” Segatori said. “We’ve assembled these molecular tools into higher-order circuits that interface with homeostatic pathways to create cellular devices with feedback-responsive, tunable behaviors.”

Guided by predictive mathematical modeling, the work is key to the development of novel therapeutic strategies and to enabling the engineering of synthetic cells with predictable behaviors as needed to enhance the production of biologics and for cell-based therapies, she said. In parallel research efforts, the Segatori group has defined the molecular pathways and cellular phenotypes triggered by nanomaterials, work that has provided key insights into optimizing cell-material interfaces.

Segatori has earned a National Science Foundation CAREER Award, and her lab has been consistently funded by the National Science Foundation, with additional support from the National Institutes of Health and private foundations. Along with her contributions to the bioengineering community, she serves on the editorial and advisory boards of numerous scientific journals.

She earned her bachelor’s degree at the University of Bologna, Italy, in 2000 and her doctorate in chemical engineering at the University of Texas at Austin in 2005.

Segatori will be inducted in a virtual ceremony March 26 during the organization’s annual meeting.

AIMBE is an organization of leaders in medical and biological engineering that consists of academic, industrial and professional society councils and elected fellows who communicate with and respond to U.S. and state government agencies and lawmakers to advocate science and contribute to policymaking that benefits the public.




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